Key result
Women with polycystic ovary syndrome and impaired fasting glucose or combined glucose intolerance demonstrated significantly higher insulin resistance (HOMA 6.1 and 6.4 vs 3.3, P<0.0001) compared to those with normal glucose tolerance.
Cross-Sectional (n=143)
Yes
Absolute Event Rate: 6.1% vs 3.3%
p-value: p=<0.0001
In patients with PCOS, increases in cardiac risk factors and free androgen levels precede overt glucose intolerance, with different insulin response patterns observed in impaired fasting glucose versus combined glucose intolerance.
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Elevated insulin resistance with early glucose intolerance in PCOS may flag cardiometabolic risk; cross-sectional data leave causal and screening implications open.
Karakas et al. (2010) conducted a cross-sectional in Polycystic Ovary Syndrome (PCOS) (n=143). Impaired fasting glucose (IFG) or combined glucose intolerance (CGI) vs. Normal glucose tolerance (NGT) was evaluated on Insulin resistance measured by homeostasis model assessment (HOMA) (p=<0.0001). Women with polycystic ovary syndrome and impaired fasting glucose or combined glucose intolerance demonstrated significantly higher insulin resistance (HOMA 6.1 and 6.4 vs 3.3, P<0.0001) compared to those with normal glucose tolerance.
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