Why the study?
Does fluvastatin 20 mg combined with ezetimibe 10 mg improve endothelial function compared to fluvastatin 60 mg in diabetic patients?
Population
24 hypercholesterolemic patients (22 with diabetes, 2 with impaired glucose tolerance), mean age ~64-65 years.
Comparison
Fluvastatin 20 mg combined with ezetimibe 10 mg… vs Fluvastatin 60 mg daily for 10 weeks
Design
RCT, randomly assigned
Follow-up
10 weeks
Authors
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High-dose statin endothelial benefits exceed LDL reduction alone; extends evidence for pleiotropic effects in diabetes.
Does fluvastatin 20 mg combined with ezetimibe 10 mg improve endothelial function compared to fluvastatin 60 mg in diabetic patients?
High-dose fluvastatin and low-dose fluvastatin combined with ezetimibe similarly improve endothelial function in diabetic patients, suggesting pleiotropic benefits of high-dose statins beyond lipid lowering.
Kawagoe et al. (2011) studied this question.
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