Why the study?
Does the combination of acebutolol and hydrochlorothiazide/amiloride reduce blood pressure more than acebutolol alone in Sudanese patients with essential hypertension?
Does the combination of acebutolol and hydrochlorothiazide/amiloride reduce blood pressure more than acebutolol alone in Sudanese patients with essential hypertension?
Adding hydrochlorothiazide/amiloride to acebutolol significantly improves blood pressure control in Sudanese patients with essential hypertension.
Supports adding hydrochlorothiazide/amiloride to acebutolol for greater BP reduction; extends combination evidence to Sudanese patients with essential hypertension.
A double-blind, crossover study was carried out in 32 Sudanese patients with essential hypertension to assess the effectiveness of single daily doses of 400 mg acebutolol when given alone and in combination with single daily doses of hydroclorothiazide/amiloride diuretic. The results show that in both groups there was a statistically significant reduction in systolic and diastolic levels throughout the treatment period. After crossover at 6 weeks, those patients initiated on acebutolol alone showed a further reduction in both systolic and diastolic pressures when the hydrochlorothiazide/amiloride combination was added. Both treatment regimens were well-tolerated and only a few side-effects were reported.
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Khalil et al. (1982) studied this question.
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