Why the study?
Does valsartan/hydrochlorothiazide reduce mean 24-h SBP compared with amlodipine in patients with essential hypertension?
Does valsartan/hydrochlorothiazide reduce mean 24-h SBP compared with amlodipine in patients with essential hypertension?
The combination of valsartan and hydrochlorothiazide is as efficacious as amlodipine in reducing ambulatory blood pressure but is better tolerated with significantly lower rates of peripheral edema.
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Valsartan/HCTZ matches amlodipine for 24-h SBP reduction; confirms comparable efficacy of ARB/diuretic combination in essential hypertension.
Franco et al. (2003) studied this question.
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