Why the study?
Does force-titrated valsartan/hydrochlorothiazide improve ambulatory blood pressure reduction compared to amlodipine/hydrochlorothiazide in patients with stage 2 hypertension?
Does force-titrated valsartan/hydrochlorothiazide improve ambulatory blood pressure reduction compared to amlodipine/hydrochlorothiazide in patients with stage 2 hypertension?
In patients with stage 2 hypertension, force-titrated valsartan/hydrochlorothiazide provides superior 24-hour ambulatory blood pressure reduction compared to amlodipine/hydrochlorothiazide, despite similar reductions in office blood pressure.
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Supports valsartan/HCTZ over amlodipine/HCTZ for superior 24-h ambulatory BP control in stage 2 hypertension; extends RCT evidence beyond office measurements.
Lacourcière et al. (2009) studied this question.
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