Why the study?
Does insulin infusion differentially affect systemic and skeletal muscle vascular resistance in lean compared to obese men?
Population
Three groups of lean (Ln) and one group of obese (Ob) men
Comparison
Insulin infusion under hyperinsulinemic… vs Basal conditions; comparison between lean and…
Design
Other
Authors
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Obese men show blunted insulin vasodilation that may heighten hypertension risk; hypothesis-generating for vascular insulin resistance as mechanistic link.
Does insulin infusion differentially affect systemic and skeletal muscle vascular resistance in lean compared to obese men?
Insulin resistance to carbohydrate metabolism is associated with resistance to insulin's vasodilatory effects in skeletal muscle, potentially acting as a risk factor for hypertension.
Baron et al. (1993) studied this question.
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