Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.
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Implication
Physiological study reveals impaired insulin-stimulated muscle blood flow in obese men, indicating a hemodynamic mechanism underlying insulin resistance.
Key Points
- To determine whether reduced skeletal muscle blood flow contributes to impaired insulin-mediated glucose uptake in obesity.
- Studied six lean men (weight 68 ± 3 kg) and six obese men (weight 94 ± 3 kg).
- Constructed insulin dose-response curves for whole-body and leg insulin-mediated glucose uptake using euglycemic clamp and leg balance techniques across multiple serum insulin concentrations.
- Dose-response curves for whole-body and leg glucose uptake, as well as arteriovenous glucose difference, were shifted rightward in obese men, showing an ED50 two- to threefold higher than lean men.
- Leg blood flow increased from basal 2.7 ± 0.2 to 4.4 ± 0.2 dl/min in lean men (P < 0.01) and from 2.5 ± 0.3 to 4.4 ± 0.4 dl/min in obese men (P < 0.01).
- The ED50 for insulin-stimulated leg blood flow was approximately fourfold higher in obese men compared to lean men (957 pmol/liter vs. 266 pmol/liter, P < 0.01).
Cite This Study
Laakso et al. (1990) studied this question.