Reduced Postprandial Skeletal Muscle Blood Flow Contributes to Glucose Intolerance in Human Obesity*
Key result
Following an oral glucose load, peak leg glucose uptake was 44% lower in obese compared to lean subjects (P<0.05), driven by a lack of postprandial increase in skeletal muscle blood flow.
Why the study?
Does an oral glucose load elicit different skeletal muscle blood flow and glucose uptake responses in obese compared to lean subjects?
Population
16 subjects, mean age 36 +/- 2 years vs. 37 +/- 2 years, weight 60 +/- 1 kg vs. 99 +/- 5 kg.
Comparison
Oral glucose load 1 g/kg administered after an… vs Lean subjects compared to obese subjects
Design
Cross-sectional
Follow-up
180 minutes
Authors
Discussion
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Implication
Obesity-linked failure of postprandial muscle hyperemia may impair glucose uptake; hypothesis-generating for vascular contributions to insulin resistance.
Key Points
- To clarify how skeletal muscle blood flow impacts glucose uptake and glucose intolerance in obesity.
- Measured whole body glucose uptake using isotope dilution; assessed leg glucose uptake through leg balance technique; evaluated leg blood flow and cardiac index in lean and obese subjects after an oral glucose load.
- Peak leg glucose uptake was 44% lower in obese subjects compared to lean subjects (P<0.05).
- Obese subjects showed no change in leg blood flow from baseline, while lean subjects had a 36% increase (P<0.05).
- Insulin levels were 2- to 3-fold higher in obese individuals at all times, indicating insulin resistance.
Study Design
Type
Observational (n=16)
Structured PICO
Does an oral glucose load elicit different skeletal muscle blood flow and glucose uptake responses in obese compared to lean subjects?
P
Population
16 subjects (8 lean and 8 obese), mean age 36 +/- 2 years (lean) vs. 37 +/- 2 years (obese), weight 60 +/- 1 kg (lean) vs. 99 +/- 5 kg (obese).
I
Intervention
Oral glucose load (OGL) 1 g/kg administered after an overnight fast
C
Comparator
Lean subjects compared to obese subjects
O
Outcome
Whole body glucose uptake (isotope dilution), leg glucose uptake (leg balance technique), leg blood flow, and cardiac index measured over 180 minutes after an oral glucose loadsurrogate
Main Result
Effect estimate: 44% lower
p-value: p=<0.05
Obesity is associated with an impaired hemodynamic response to an oral glucose load, specifically a lack of increase in skeletal muscle blood flow, which contributes to reduced glucose tolerance and insulin resistance.
Cite This Study
Baron et al. (1990) conducted an observational in Obesity (n=16). Oral glucose load vs. Lean subjects was evaluated on Peak leg glucose uptake (44% lower, p=<0.05). Following an oral glucose load, peak leg glucose uptake was 44% lower in obese compared to lean subjects (P<0.05), driven by a lack of postprandial increase in skeletal muscle blood flow.