Key result
Administration of 4-factor prothrombin complex concentrate improved all thrombin generation measures and yielded a favorable outcome in a patient with rivaroxaban-associated subdural hematoma.
Why the study?
Does 4-factor prothrombin complex concentrate reverse rivaroxaban-induced coagulopathy in a patient with spontaneous subdural hematoma?
Population
1 patient receiving rivaroxaban prophylaxis who developed a spontaneous subdural hematoma
Design
Case_report
Authors
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4-factor PCC may aid rivaroxaban reversal in subdural hematoma; leaves open confirmation in prospective trials.
Case Report (n=1)
Does 4-factor prothrombin complex concentrate reverse rivaroxaban-induced coagulopathy in a patient with spontaneous subdural hematoma?
4-factor prothrombin complex concentrate may be an effective reversal agent for rivaroxaban-associated life-threatening bleeding, as assessed by thrombin generation tests.
Kauffmann et al. (2015) conducted a case report in Rivaroxaban-associated spontaneous subdural hematoma (n=1). 4-factor prothrombin complex concentrate was evaluated on Thrombin generation measures. Administration of 4-factor prothrombin complex concentrate improved all thrombin generation measures and yielded a favorable outcome in a patient with rivaroxaban-associated subdural hematoma.
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