Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6, on Reperfusion-Induced Arrhythmia in Rats

86 male Sprague-Dawley rats (300-450 g) subjected to 4 minutes of left coronary artery occlusion followed by 4 minutes of reperfusion.

ST-6 (2-[4-[4-(chlorophenyl)-4-hydroxy-1-piperidinyl]butyl]hexahydro-1H-isoindol-1,3(2H)-dione) administered via intravenous bolus (0.1 to 2.0 mg/kg), intraperitoneal injection (2 to 10 mg/kg), intraduodenal injection (10 mg/kg), or intravenous infusion (0.2 mg/kg per min).

Saline vehicle control. Additional active comparators included lidocaine (0.1 mg/kg per min), sematilide (0.3 mg/kg per min), and diltiazem (0.5 mg/kg per min).

Incidence of ventricular fibrillation and mortality at the end of 4-minute reperfusion.surrogate