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Cascade alkylarylation produces oxindole derivatives in a lab setting, indicating potential anti-inflammatory effects.
Herein, we developed a cascade alkylarylation reaction of N-arylacrylamides with carboxylic acids to construct 3,3-disubstituted oxindole derivatives. The transformation employs inexpensive iron photocatalysis under visible light irradiation. A broad scope of carboxylic acids and N-arylacrylamides could be well tolerated. Additionally, several synthesized oxindole compounds showed the suppression of nitric oxide generation in LPS-induced RAW 264.7 macrophage cells.
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Zhang et al. (2025) studied this question.
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