Why the study?
Does a test dose of chlorpromazine and discriminant function analysis improve treatment response prediction in newly admitted schizophrenic patients?
Population
60 newly admitted schizophrenic patients (37 in initial cohort, 23 in validation cohort)
Comparison
Discriminant function analysis using a test dose… vs Standard open and flexible dosage of…
Design
Cohort, open
Follow-up
3 months (initial cohort), 4 weeks (validation cohort)
Authors
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May support test-dose prediction for antipsychotics in acute schizophrenia; leaves open need for RCT confirmation before practice change.
Does a test dose of chlorpromazine and discriminant function analysis improve treatment response prediction in newly admitted schizophrenic patients?
Using a test dose of chlorpromazine to predict drug response may improve overall treatment efficacy in newly admitted schizophrenic patients.
Minami et al. (1997) studied this question.
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