Why the study?
Do chlorpromazine plasma levels correlate with physiologic and clinical effects in patients with functional psychoses?
Population
10 patients suffering from functional psychoses who had not received medication for one month
Design
Cohort
Follow-up
5 to 6 weeks
Authors
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May warrant exploring plasma monitoring in nonresponders with autonomic effects; leaves open correlation with clinical efficacy in psychoses.
Do chlorpromazine plasma levels correlate with physiologic and clinical effects in patients with functional psychoses?
Chlorpromazine plasma levels show wide interpatient variation and correlate with peripheral autonomic measures, suggesting utility in investigating nonresponders and patients with severe autonomic effects.
Sakalis et al. (1972) studied this question.
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