Key result
Intravenous chlorpromazine elevates PRA and aldosterone levels in schizophrenic patients.
Why the study?
Does intravenous chlorpromazine affect plasma renin activity and aldosterone levels in schizophrenic patients?
Population
Schizophrenic patients on a normal sodium diet, evaluated in a supine position
Design
Cohort
Follow-up
60 minutes
Authors
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May confound RAAS evaluation in chlorpromazine-treated patients; leaves open generalizability beyond this schizophrenic cohort.
Does intravenous chlorpromazine affect plasma renin activity and aldosterone levels in schizophrenic patients?
Intravenous chlorpromazine increases plasma renin activity and aldosterone levels, which may confound the clinical evaluation of the renin-angiotensin-aldosterone system in patients receiving this medication.
Robertson et al. (1975) studied Schizophrenia. Chlorpromazine was evaluated on Plasma renin activity (PRA) and aldosterone levels. Intravenous administration of chlorpromazine increased plasma renin activity and aldosterone levels in schizophrenic patients, with maximum levels occurring 60 minutes after the higher dose.
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