Dopaminergic Modulation of Aldosterone Secretion in Man is Unaffected by Glucocorticoids and Angiotensin Blockade
Why the study?
Does metoclopramide stimulate aldosterone secretion independently of glucocorticoids and angiotensin blockade in normal men?
Population
9 normal male volunteers in metabolic balance at 100 meq sodium/day and 60 meq potassium/day constant intake
Comparison
Metoclopramide administered with 5% dextrose… vs Placebo or vehicle (5% dextrose)
Design
Other
Follow-up
Short-term (minutes to days)
Authors
Discussion
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Member takes
Implication
Supports dopaminergic aldosterone stimulation in normal men; hypothesis-generating for clinical effects in hypertension or HF.
Structured PICO
Does metoclopramide stimulate aldosterone secretion independently of glucocorticoids and angiotensin blockade in normal men?
P
Population
9 normal male volunteers in metabolic balance at 100 meq sodium/day and 60 meq potassium/day constant intake
I
Intervention
Metoclopramide (10 mg iv) administered with 5% dextrose (vehicle), dopamine (3 µg/kg-min), saralasin (10 µg/kg-min), or after 4 days of dexamethasone (2 mg orally every 6 h)
C
Comparator
Placebo or vehicle (5% dextrose)
O
Outcome
Plasma aldosterone concentrationssurrogate
Metoclopramide stimulates aldosterone secretion through dopaminergic antagonism, independent of prolactin, ACTH, electrolytes, and the renin-angiotensin system.
Cite This Study
Sowers et al. (1981) studied this question.