Why the study?
Does dopamine infusion reduce the aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with low-renin essential hypertension and idiopathic hyperaldosteronism?
Does dopamine infusion reduce the aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with low-renin essential hypertension and idiopathic hyperaldosteronism?
Dopamine reduces the exaggerated aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with low-renin essential hypertension and idiopathic hyperaldosteronism, suggesting an increased but ineffective dopamine inhibition in these conditions.
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Dopamine may blunt aldosterone responses in low-renin states; hypothesis-generating and should not yet change practice.
Witzgall et al. (1985) studied this question.
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