Why the study?
Does metoclopramide enhance the aldosterone response to infused angiotensin II in normal subjects on high sodium diets?
Population
6 normal subjects in metabolic balance on diets containing both 10 and 200 meq Na/day
Comparison
Metoclopramide during graded infusions of… vs Control graded infusions of angiotensin II…
Design
Other
Authors
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May support dopaminergic modulation of aldosterone on high-sodium diets; leaves open any clinical role in hypertension.
Does metoclopramide enhance the aldosterone response to infused angiotensin II in normal subjects on high sodium diets?
Dopamine antagonism with metoclopramide restores aldosterone responsiveness to angiotensin II during high sodium intake, suggesting dopamine mediates the blunted aldosterone secretion seen with sodium loading.
Gordon et al. (1983) studied this question.
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