January 1, 1984Endocrinology
Dopaminergic Modulation of Aldosterone Secretion in the Rat
Population
Rats maintained on normal or high sodium intake, and collagenase-dispersed adrenal glomerulosa cells
Comparison
Minipump infusion of metoclopramide and/or… vs Baseline conditions, normal vs high sodium…
Design
Preclinical
Follow-up
2 days
Authors
Discussion
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Member takes
Implication
Does not support clinical changes in aldosterone management; leaves open dopaminergic modulation of AII effects in adrenal models.
Structured PICO
P
Population
Rats maintained on normal or high sodium intake, and collagenase-dispersed adrenal glomerulosa cells
I
Intervention
Minipump infusion of metoclopramide (MCP) (1.2 micrograms/min iv) and/or angiotensin II (AII) (25 ng/min sc) for 2 days; dopamine infusion (2 micrograms/min)
C
Comparator
Baseline conditions, normal vs high sodium intake, and single infusions (AII or MCP alone)
O
Outcome
Plasma aldosterone levels, adrenal capsular AII receptors, and 18-hydroxylase activitysurrogate
Metoclopramide exerts a permissive action on the trophic effects of angiotensin II on adrenal cells during high sodium intake via dopaminergic antagonism, likely through the liberation of other local regulators.
Cite This Study
Aguilera et al. (1984) studied this question.