Why the study?
Does metoclopramide stimulate aldosterone production in rats?
Population
Rats (conscious, and conscious unrestrained chronically cannulated) and isolated zona glomerulosa cells
Comparison
Metoclopramide via ip injection, intraarterial… vs Basal conditions or stimulation with potassium…
Design
Preclinical
Follow-up
10-15 min post injection for plasma measurements
Authors
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No aldosterone stimulation by metoclopramide in rats; leaves open species differences or serotonin antagonism in humans.
Does metoclopramide stimulate aldosterone production in rats?
Metoclopramide does not stimulate aldosterone production in rats, suggesting species differences or a serotonin antagonist property.
Campbell et al. (1981) studied this question.
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