Why the study?
Does metoclopramide increase plasma aldosterone in supine volunteers?
Population
9 supine volunteers on a hospital diet
Comparison
Metoclopramide 10 mg IV bolus vs Placebo IV bolus
Design
RCT, random, double blind
Follow-up
1 hour
Authors
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Metoclopramide may confound aldosterone measurements; confirms tonic dopaminergic inhibition of secretion.
Does metoclopramide increase plasma aldosterone in supine volunteers?
Metoclopramide administration increases plasma aldosterone, suggesting a tonic inhibitory influence of dopamine on aldosterone secretion.
Noth et al. (1980) studied this question.
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