February 1, 1982The Journal of Clinical Endocrinology & Metabolism
Acute Dopaminergic Inhibition of Aldosterone Secretion Is Independent of Angiotensin II and Adrenocorticotropin*
Why the study?
Does dopamine infusion inhibit angiotensin II-, ACTH-, or metoclopramide-induced aldosterone secretion in normal male subjects?
Population
6 normal male subjects in metabolic balance on a 150 meq/day sodium and 60 meq/day potassium intake
Comparison
Dopamine infusion during stimulation with… vs Vehicle infusion during stimulation with…
Design
Other
Follow-up
acute (during infusion)
Authors
Discussion
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Member takes
Implication
Dopamine selectively inhibits metoclopramide-induced aldosterone secretion in normals; leaves open relevance to hyperaldosteronism.
Structured PICO
Does dopamine infusion inhibit angiotensin II-, ACTH-, or metoclopramide-induced aldosterone secretion in normal male subjects?
P
Population
6 normal male subjects in metabolic balance on a 150 meq/day sodium and 60 meq/day potassium intake
I
Intervention
Dopamine infusion (4 micrograms/kg . min) during stimulation with angiotensin II (AII), ACTH, or metoclopramide
C
Comparator
Vehicle infusion during stimulation with angiotensin II (AII), ACTH, or metoclopramide
O
Outcome
Plasma aldosterone concentration (PAC)surrogate
Dopaminergic inhibition of aldosterone secretion is independent of angiotensin II and ACTH, but inhibits metoclopramide-induced secretion.
Cite This Study
Robert M. Carey (1982) studied this question.