Effects of Metoclopramide and Bromocriptine on the Renin-Angiotensin-Aldosterone System in Man
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Why the study?
Does dopaminergic blockade with metoclopramide or stimulation with bromocriptine alter the renin-angiotensin-aldosterone system in normal men?
Population
6 normal white male volunteer subjects, aged 24-30 years, with normal arterial blood pressures and no…
Comparison
Metoclopramide 10 mg IV bolus, or bromocriptine… vs Matching placebo followed by angiotensin II…
Design
Other, single-blind
Follow-up
acute (hours)
Authors
Discussion
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Implication
Indicates tonic dopaminergic inhibition of aldosterone in healthy men; hypothesis-generating and should not change practice.
Structured PICO
Does dopaminergic blockade with metoclopramide or stimulation with bromocriptine alter the renin-angiotensin-aldosterone system in normal men?
P
Population
6 normal white male volunteer subjects, aged 24-30 years, with normal arterial blood pressures and no history of renal disease, in metabolic balance at 150 meq sodium and 60 meq potassium constant intake.
I
Intervention
Metoclopramide 10 mg IV bolus, or bromocriptine 2.5 mg orally (3 doses at 6 p.m., midnight, and 6 a.m.), followed by angiotensin II infusion (2, 4, and 6 pmol/kg per min for 30 min each).
C
Comparator
Matching placebo (IV or oral) followed by angiotensin II infusion.
O
Outcome
Plasma aldosterone concentration and plasma prolactin concentration.surrogate
This physiological study suggests that aldosterone production is under maximum tonic dopaminergic inhibition in normal humans, which can be overridden by angiotensin II stimulation.
Limitations
- Small sample size
- Aldosterone secretion rates or metabolic clearance studies were not performed
Cite This Study
Carey et al. (1979) studied this question.
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