April 1, 1983Endocrinology

Specificity of Metoclopramide in Assessing the Role of Dopamine in Regulating Aldosterone Secretion*

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Population

Rat glomerulosa cells

Comparison

Dopamine, metoclopramide, and serotonin, alone… vs Basal conditions, angiotensin II alone, or…

Design

Preclinical

Authors

LBLynne M. BraleyBrigham and Women's Hospital AMALPHONSA MENACHERYBrigham and Women's Hospital GWGordon H. WilliamsPreventive Cardiology

Discussion

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Implication

Indicates dopaminergic inhibition of aldosterone in vitro; leaves open relevance to human physiology or clinical use.

Structured PICO

Population

Rat glomerulosa cells

Intervention

Dopamine (1 × 10-10 to 1 × 10-6 M), metoclopramide (1 × 10-10 and 1 × 10-7 M), and serotonin (1 × 10-8 and 1 × 10-6 M), alone and in combination

Comparator

Basal conditions, angiotensin II (AII) alone, or serotonin alone

Outcome

Aldosterone secretion/productionsurrogate

Metoclopramide has complex effects on aldosterone secretion in vitro, acting as an antagonist to both dopamine and serotonin, which have opposite actions on the adrenal gland.

Cite This Study

Braley et al. (1983) studied this question.

synapsesocial.com/papers/6a86d0f6bb0787ff27ca098f https://doi.org/10.1210/endo-112-4-1352

View Full Paper

Ask AI

Bookmark

Specificity of Metoclopramide in Assessing the Role of Dopamine in Regulating Aldosterone Secretion*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specificity of Metoclopramide in Assessing the Role of Dopamine in Regulating Aldosterone Secretion*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider