October 1, 1980Endocrinology
Dopaminergic Modulation of Aldosterone Secretion Is Independent of Alterations in Renin Secretion*
Why the study?
Is dopaminergic modulation of aldosterone secretion mediated through the renin-angiotensin system in rats?
Population
Rats (including a subset studied 36 h after bilateral nephrectomy)
Comparison
Intraarterial administration of metoclopramide… vs Baseline levels and responses without specific…
Design
Preclinical
Follow-up
30 minutes post-administration
Authors
Discussion
Loading...
Member takes
Implication
Supports RAS-independent dopaminergic aldosterone control in rats; hypothesis-generating and should not alter clinical practice.
Structured PICO
Is dopaminergic modulation of aldosterone secretion mediated through the renin-angiotensin system in rats?
P
Population
Rats (including a subset studied 36 h after bilateral nephrectomy)
I
Intervention
Intraarterial administration of metoclopramide (MCP), a dopamine antagonist, with or without pretreatments (L-dopa 30 mg/kg, SQ 14,225 1 mg/kg, or saralasin 10 micrograms/kg min-1)
C
Comparator
Baseline levels and responses without specific pretreatments
O
Outcome
Plasma aldosterone (PA) and plasma renin activity (PRA) levelssurrogate
This preclinical study demonstrates that dopaminergic modulation of aldosterone secretion occurs independently of the renin-angiotensin system.
Cite This Study
Sowers et al. (1980) studied this question.