January 1, 1981Clinical and Experimental Hypertension
Dopaminergic Modulation of Renin Release
Why the study?
Does dopaminergic modulation with metoclopramide or L-dopa alter plasma renin activity in adult rats?
Population
Adult rats (American Wistar, spontaneously hypertensive rats, and Wistar Kyoto normotensive controls)
Comparison
Intravenous bolus of metoclopramide or L-dopa vs Wistar Kyoto normotensive controls and baseline…
Design
Preclinical
Follow-up
up to 40 minutes
Authors
Discussion
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Implication
Supports dopaminergic renin control in rats; hypothesis-generating, no clinical translation yet.
Structured PICO
Does dopaminergic modulation with metoclopramide or L-dopa alter plasma renin activity in adult rats?
P
Population
Adult rats (American Wistar, spontaneously hypertensive rats, and Wistar Kyoto normotensive controls)
I
Intervention
Intravenous bolus of metoclopramide (200 microgram/kg) or L-dopa (30 mg/kg)
C
Comparator
Wistar Kyoto (WKY) normotensive controls (for the spontaneously hypertensive rat comparison) and baseline measurements
O
Outcome
Plasma renin activity (PRA)surrogate
Dopaminergic modulation exerts inhibitory control over renin secretion, a mechanism that appears altered in spontaneously hypertensive rats.
Cite This Study
Sowers et al. (1981) studied this question.