September 1, 1980Experimental Biology and Medicine
Dopaminergic Modulation of Renin Activity and Aldosterone and Prolactin Secretion in the Spontaneously Hypertensive Rat
Population
8 spontaneously hypertensive rats (SHR) and 8 Wistar-Kyoto normotensive rats (WKY)
Comparison
Metoclopramide (dopamine antagonist) and L-dopa vs Wistar-Kyoto normotensive rats (WKY)
Design
Preclinical
Authors
Discussion
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Implication
Should not change clinical practice; leaves open dopaminergic dysregulation as a factor in human hypertension pathogenesis.
Structured PICO
P
Population
8 spontaneously hypertensive rats (SHR) and 8 Wistar-Kyoto normotensive rats (WKY)
I
Intervention
Metoclopramide (dopamine antagonist) and L-dopa
C
Comparator
Wistar-Kyoto normotensive rats (WKY)
O
Outcome
Plasma aldosterone (PA), plasma renin activity (PRA), and plasma prolactin (PRL)surrogate
Spontaneously hypertensive rats exhibit altered dopaminergic modulation of aldosterone, renin, and prolactin secretion, suggesting a role for dopamine control in essential hypertension pathogenesis.
Cite This Study
Sowers et al. (1980) studied this question.