Population
Spontaneously hypertensive rats, normotensive Kyoto-Wistar rats, and normotensive Sprague-Dawley rats
Comparison
Low or high sodium diet for 10 days; in vitro… vs Normotensive control rats (WKY and SDR)
Design
Preclinical
Follow-up
10 days
Authors
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Supports Ang II-specific aldosterone defect in SHR; leaves open translation to human hypertension mechanisms.
The defect in aldosterone secretion in spontaneously hypertensive rats is specific to the angiotensin II pathway, rather than a generalized defect in hormonal regulation.
Braley et al. (1983) studied this question.
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