Why the study?
Does dopamine mediate the altered aldosterone response to Angiotensin II or the sodium-retaining tendency in nonmodulating hypertension?
Does dopamine mediate the altered aldosterone response to Angiotensin II or the sodium-retaining tendency in nonmodulating hypertension?
The sodium-retaining tendency in nonmodulating hypertension may be driven by a failure to increase intrarenal dopamine production in response to a sodium load, rather than increased dopaminergic inhibition of aldosterone secretion.
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May implicate defective renal dopamine response in sodium retention of nonmodulating hypertension; hypothesis-generating and requires prospective confirmation.
Williams et al. (1990) studied this question.
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