Key result
Chlorpromazine at 600 mg daily for 24 weeks increased serum cholesterol by 14 to 28 mg/100 ml compared to placebo in chronic schizophrenic patients.
Why the study?
Does chlorpromazine increase serum cholesterol concentrations in chronic schizophrenic patients?
Population
Chronic schizophrenic patients from 6 separate controlled clinical trials
Comparison
Chlorpromazine at fixed daily doses of 150 mg… vs Placebo
Design
Meta-analysis
Follow-up
24 weeks
Authors
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Alerts clinicians to monitor lipids with high-dose chlorpromazine; confirms hypercholesterolemic effects in chronic schizophrenia.
RCT
Does chlorpromazine increase serum cholesterol concentrations in chronic schizophrenic patients?
Effect estimate: MD 14 to 28 mg/100 ml
High-dose chlorpromazine (600 mg daily) exhibits hypercholesterolemic activity in chronic schizophrenic patients, suggesting a potential atherogenic role with long-term use.
Clark et al. (1970) conducted an RCT in Chronic schizophrenia. Chlorpromazine vs. Placebo was evaluated on Serum cholesterol concentrations (MD 14 to 28 mg/100 ml). Chlorpromazine at 600 mg daily for 24 weeks increased serum cholesterol by 14 to 28 mg/100 ml compared to placebo in chronic schizophrenic patients.
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