What question did this study set out to answer?

The aim is to investigate how chlorpromazine interacts with lipid membranes, particularly focusing on the role of phosphatidylserine.

The impact of charge on chlorpromazine interaction with lipid membranes

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Demonstrates how chlorpromazine interacts with membrane lipids, implying potential implications for psychiatric treatment efficacy.

The aim is to investigate how chlorpromazine interacts with lipid membranes, particularly focusing on the role of phosphatidylserine.
Examined interactions of chlorpromazine with phosphatidylcholine bilayers.
Included a mixture of phosphatidylserine to assess its impact on lipid membranes.
Utilized complementary techniques to analyze membrane properties and drug affinities.
Chlorpromazine showed a higher affinity for phosphatidylserine headgroups.
Enhanced penetration of chlorpromazine into membranes containing phosphatidylserine.
Higher drug retention observed in anionic lipid bilayers compared to zwitterionic phosphatidylcholine alone.
At high concentrations, chlorpromazine induced the formation of mixed micelles on the membranes.

Gorše et al. (2026) studied this question.

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