Why the study?
Does pimozide improve clinical symptoms compared to chlorpromazine in patients with mania?
Population
23 patients who fulfilled Feighner's criteria for mania (one patient entering on two separate occasions)
Comparison
Pimozide (PMZ) for 14 days vs Chlorpromazine (CPZ) for 14 days
Design
RCT, double-blind
Follow-up
14 days
Authors
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Pimozide matches chlorpromazine for acute mania; confirms central dopamine hyperactivity in pathogenesis.
Does pimozide improve clinical symptoms compared to chlorpromazine in patients with mania?
Pimozide is as effective as chlorpromazine in the treatment of mania, supporting the hypothesis that hyperactivity of central dopamine pathways is involved in its pathogenesis.
Cookson et al. (1981) studied this question.