Five manic patients were treated with chlorpromazine hydrochloride (CPZ), then with L-tryptophan (LTP), and five with LTP first, then CPZ, in a double-blind, placebo-controlled crossover study. LTP was slightly superior to CPZ in all regards. Mania and depression may be linked by a central indoleamine deficit.
No takes yet. Share an insight, caveat, or question.
Arthur J. Prange (1974) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: