February 1, 1988Annals of Neurology
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
Authors
Discussion
Loading...
Member takes
Implication
Randomized trial examines peptide release in humans and cats, highlighting insights into headache treatment.
Key Points
- This research aims to investigate the release of vasoactive peptides during the activation of the trigeminal ganglion in humans and cats.
- Blood samples were collected from intravenous access during trigeminal ganglion activation in humans and cats.
- Thermocoagulation was used in humans, while electrical stimulation was employed in cats to activate the trigeminal system.
- Peptide levels of substance P and CGRP were measured to assess their response to the activation.
- Flushing patients exhibited marked elevations in cranial peptide levels, while non-flushing patients showed no significant changes.
- In cats, substance P-like and CGRP-like immunoreactivity increased significantly during trigeminal ganglion stimulation.
Cite This Study
Goadsby et al. (1988) studied this question.