Key result
High-risk pregnant women destined to develop preterm pre-eclampsia exhibited a significantly higher prevalence of altered cardiac geometry (62.5%) and diastolic dysfunction (62.5%) at mid-gestation compared to those developing term pre-eclampsia.
Why the study?
Pre-eclampsia is linked to maternal cardiac remodelling and diastolic dysfunction, but whether mid-gestational cardiovascular profiles differ between women destined to develop preterm versus term pre-eclampsia was unclear.
Does the maternal cardiovascular profile at mid-gestation differ in nulliparous women destined to develop preterm pre-eclampsia versus term pre-eclampsia or uneventful outcomes?
Population
115 nulliparous mid-gestational pregnant women with singleton pregnancy
Comparison
Low risk uneventful vs high risk uneventful vs high risk term PE vs high risk preterm PE
Design
Prospective study
Authors
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May flag preterm pre-eclampsia risk via mid-gestation cardiac screening; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=115)
Single-blind
No
Does the maternal cardiovascular profile at mid-gestation differ in nulliparous women destined to develop preterm pre-eclampsia versus term pre-eclampsia or uneventful outcomes?
Absolute Event Rate: 62.5% vs 23.1%
p-value: p=0.000
Asymptomatic cardiac diastolic dysfunction, impaired relaxation, and altered geometry at mid-gestation are detectable in high-risk pregnant women destined to develop preterm pre-eclampsia, providing early markers for cardiovascular risk.
Sahu et al. (2019) conducted a cohort in Pre-eclampsia (n=115). Development of preterm pre-eclampsia vs. Development of term pre-eclampsia was evaluated on Altered cardiac geometry at mid-gestation (p=0.000). High-risk pregnant women destined to develop preterm pre-eclampsia exhibited a significantly higher prevalence of altered cardiac geometry (62.5%) and diastolic dysfunction (62.5%) at mid-gestation compared to those developing term pre-eclampsia.
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