Population
Cloned satellite cells isolated from adult human skeletal muscle
Comparison
In vitro myogenesis over a 15-day time course vs Fetal and adult human skeletal muscle
Design
Preclinical
Follow-up
15-day time course
Authors
Loading...
Discordant transcript regulation in animal myogenesis warrants caution against clinical extrapolation; leaves open gene-specific mechanisms in human muscle disease.
During human myogenesis, muscle-specific genes display highly variable and discordant patterns of mRNA accumulation, suggesting unique regulatory determinants for individual genes.
Gunning et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: