Why the study?
Does losartan reduce the rate of renal function loss in hypertensive patients with advanced renal insufficiency?
Population
8 hypertensive patients with chronic renal disease and advanced renal insufficiency, mean age 55.6, 75%…
Comparison
Losartan 25-50 mg/day oral for 24 weeks vs Pre-treatment period
Design
Cohort
Follow-up
24 weeks
Key result
Losartan significantly retarded the progression of advanced renal insufficiency, improving the 1/sCr slope from -0.004 to -0.001 dl/mg/week over 24 weeks.
Authors
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Supports losartan for slowing renal decline in advanced insufficiency; hypothesis-generating, needs randomized confirmation before practice change.
Observational (n=8)
No
Does losartan reduce the rate of renal function loss in hypertensive patients with advanced renal insufficiency?
Absolute Event Rate: -0.001% vs -0.004%
p-value: p=<0.05
In a small retrospective cohort, losartan significantly slowed the decline of renal function in patients with advanced renal insufficiency, independent of significant blood pressure changes.
Osawa et al. (2006) conducted an observational in Advanced renal insufficiency (n=8). Losartan vs. Pre-treatment period was evaluated on Slope of reciprocal of serum creatinine plotted against time (1/sCr slope) (p=<0.05). Losartan significantly retarded the progression of advanced renal insufficiency, improving the 1/sCr slope from -0.004 to -0.001 dl/mg/week over 24 weeks.
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