Key result
Thorough QT/QTc assessment is an inadequate surrogate for proarrhythmia, as torsade de pointes is lethal in <20% of instances; extraction of TRIaD from the T-wave is recommended instead.
Design
Review
Authors
Loading...
May warrant caution using QT/QTc as sole proarrhythmia surrogate; leaves open TRIaD validation in drug safety assessment.
The paper argues against relying solely on QT prolongation for assessing drug proarrhythmic risk, advocating instead for the evaluation of TRIaD parameters from the T-wave to better predict both torsade de pointes and ventricular fibrillation.
Luc M. Hondeghem (2006) conducted a review in Drug-induced QT prolongation and proarrhythmia. Thorough QT/QTc assessment was evaluated. Thorough QT/QTc assessment is an inadequate surrogate for proarrhythmia, as torsade de pointes is lethal in <20% of instances; extraction of TRIaD from the T-wave is recommended instead.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: