Key result
Drug-induced QT prolongation and subsequent arrhythmogenesis cannot be fully understood solely through the simple numerical measurement of the QT interval.
Design
Review
Authors
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Clinicians should interpret QT prolongation cautiously for proarrhythmia risk; leaves open validation of multimodal repolarization metrics.
This review emphasizes that simple QT interval measurements are inadequate for fully assessing the risk of drug-induced proarrhythmia and torsade de pointes.
Ahmad et al. (2007) conducted a review in Drug-induced QT prolongation and proarrhythmia. QT-prolonging drugs was evaluated. Drug-induced QT prolongation and subsequent arrhythmogenesis cannot be fully understood solely through the simple numerical measurement of the QT interval.
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