Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes
Population
Protein sequences containing the purine NTP-binding motif, including 25 established or putative helicases of…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical impact; leaves open functional roles of this helicase superfamily in mammalian models.
Structured PICO
P
Population
Protein sequences containing the purine NTP-binding motif, including 25 established or putative helicases of Escherichia coli, yeast, insects, mammals, pox- and herpesviruses, a yeast mitochondrial plasmid and three groups of positive strand RNA viruses
I
Intervention
Systematic analysis of protein sequences and secondary structure predictions
O
Outcome
Identification of conserved segments and consensus patterns
Identifies a new superfamily of putative helicases with conserved segments involved in DNA and RNA genome replication, recombination, repair, and expression.
Cite This Study
Gorbalenya et al. (1989) studied this question.