Key result
During a cold pressor test, women exhibited smaller increases in mean arterial pressure (7 vs 10 mmHg; P=0.03) and femoral vascular resistance than men, unpredicted by sympathetic nerve activity.
Why the study?
Muscle sympathetic nerve activity affects vascular resistance differently in women and men, but whether this sex difference persists during pronounced increases in sympathetic activity remains unclear.
Do sex differences exist in neurovascular and neurohemodynamic relationships during cold pressor test-mediated sympathoexcitation in young healthy adults?
Population
11 young healthy women and 10 young healthy men
Comparison
Women vs men during cold pressor test
Authors
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Sex-specific hemodynamic responses to sympathoexcitation may occur independently of nerve activity; hypothesis-generating and requires prospective validation before clinical consideration.
Cross-Sectional (n=21)
Do sex differences exist in neurovascular and neurohemodynamic relationships during cold pressor test-mediated sympathoexcitation in young healthy adults?
Absolute Event Rate: 7% vs 10%
p-value: p=0.03
In young healthy adults, men experience robust blood pressure responses driven by neurovascular coupling during sympathetic activation, whereas this relationship is absent in women.
Coovadia et al. (2022) conducted a cross-sectional in Healthy (n=21). Female sex vs. Male sex was evaluated on CPT-induced increase in mean arterial pressure (mmHg) (p=0.03). During a cold pressor test, women exhibited smaller increases in mean arterial pressure (7 vs 10 mmHg; P=0.03) and femoral vascular resistance than men, unpredicted by sympathetic nerve activity.
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