Key result
In chronic dialysis patients, being in the lowest quartile of self-assessed physical health on the SF-12 was associated with a 2.5-fold higher adjusted risk of mortality compared to the highest quartile.
Why the study?
Does the SF-12 health survey predict mortality as effectively as the SF-36 in chronic dialysis patients?
Cohort (n=252)
Yes
Does the SF-12 health survey predict mortality as effectively as the SF-36 in chronic dialysis patients?
The shorter SF-12 health survey provides similar predictions of mortality as the SF-36 in chronic dialysis patients, making it a more practical clinical tool.
Answers are grounded in this paper and cite their sources.
Low SF-12 physical scores flag elevated mortality risk in dialysis; supports shorter survey utility but leaves direct SF-36 equivalence open.
BACKGROUND: To assess health- related quality of life (HRQOL) with SF-12 and SF-36 and compare their abilities to predict mortality in chronic dialysis patients, after adjusting for traditional risk factors. METHODS: The Short-Form Health Survey (SF-36) with the embedded SF-12 was applied in 301 dialysis patients cross-sectionally. Physical and mental component summary (PCS-36, MCS-36, PCS-12, and MCS-12) scores were calculated. Clinical and demographic data were collected. Mortality (followed for up to 4.5 years) was analyzed with Kaplan Meier plots and Cox proportional hazards, after censoring for renal transplantation. Exclusion factors were observation time <2 months (n = 21) and missing component summary scores (n = 10 for SF-36; n = 28 for SF-12), thus 252 patient were included in the analyses. RESULTS: In 252 patients (60.2 ± 15.5 years, 65.9% males, dialysis vintage 9.0, IQR 5.0-23.0 months), mortality during follow-up was 33.7%.(85 deaths). Significant correlations were observed between PCS-36 and PCS-12 (ρ = 0.93, p < 0.001) and between MCS-36 and MCS-12 (ρ = 0.95, p < 0.001). Mortality rate was highest in patients in the lowest quartile of PCS-12 (χ² = 15.3, p = 0.002) and PCS-36 (χ² = 16.7, p = 0.001). MCS was not associated with mortality. Adjusted hazard ratios for mortality were 2.5 (95% CI 1.0-6.3, PCS-12) and 2.7 (1.1 - 6.4, PCS-36) for the lowest compared with the highest ("best perceived") quartile of PCS. CONCLUSION: Compromised HRQOL is an independent predictor of poor outcome in dialysis patients. The SF-12 provided similar predictions of mortality as SF-36, and may serve as an applicable clinical tool because it requires less time to complete.
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Østhus et al. (2012) conducted a cohort in End-stage renal disease on chronic dialysis (n=252). Lowest quartile of physical component summary score (PCS-12) vs. Highest quartile of physical component summary score (PCS-12) was evaluated on Mortality (HR 2.5, 95% CI 1.0-6.3, p=0.048). In chronic dialysis patients, being in the lowest quartile of self-assessed physical health on the SF-12 was associated with a 2.5-fold higher adjusted risk of mortality compared to the highest quartile.
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