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Neuroblastoma is a unique tumor of childhood that has a wide range of malignant expression. The prognoses range from excellent, with minimal treatment required, for patients with localized tumors or a special pattern of widespread disease to very poor for those with skeletal metastases. In some patients, the tumor regresses spontaneously. Spontaneous regression is predictable in infants who have small primary tumors and a particular distribution of disseminated disease with neuroblastoma in the liver, skin, bone marrow, or any combination of the three sites. Such infants, with disease classified as Stage IV-S, have a different prognosis from those with Stage . . .
Maris et al. (Thu,) studied this question.