Indapamide, but not chlorthalidone, directly blocks the slow component of the delayed rectifier K+ current (IKs) in guinea pig ventricular myocytes, suggesting a potential direct mechanism for diuretic-induced QT prolongation.
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Indapamide may prolong QT via IKs block in animals; leaves open clinical relevance and human translation.
Turgeon et al. (1994) studied this question.
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