Why the study?
Does angiotensin-(1-7), alone or in combination with bradykinin, affect forearm blood flow in patients with heart failure treated with ACE inhibitors?
Does angiotensin-(1-7), alone or in combination with bradykinin, affect forearm blood flow in patients with heart failure treated with ACE inhibitors?
Angiotensin-(1-7) is biologically inactive in the forearm circulation of heart failure patients on ACE inhibitors, challenging previous preclinical assumptions about its hemodynamic relevance.
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Should not change heart failure management; hypothesis-generating and challenges preclinical assumptions of angiotensin-(1-7) activity.
Davie et al. (1999) studied this question.
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