Key result
In normotensive hemodialysis patients, left ventricular ejection fraction was an independent predictor of all-cause mortality, with a 3% reduction in risk per 1% increase in LVEF.
Why the study?
Does LVEF predict all-cause and cardiovascular mortality in normotensive hemodialysis patients?
Cohort (n=145)
Yes
Does LVEF predict all-cause and cardiovascular mortality in normotensive hemodialysis patients?
LVEF is an independent predictor of all-cause and cardiovascular mortality in normotensive hemodialysis patients.
Answers are grounded in this paper and cite their sources.
LVEF may refine mortality risk stratification in normotensive hemodialysis; hypothesis-generating and requires prospective validation.
BACKGROUND: Normotension has been hold to be the goal of hemodialysis. It remains obscure which cardiovascular parameter determines the prognosis in these normotensive hemodialysis patients. METHODS: We prospectively enrolled 145 hemodialysis patients, who had attained normotension without anti-hypertensive medications, and followed them for 72.6 ± 28.5 months. Important cardiovascular parameters were obtained at enrollment. Predictors for all-cause and cardiovascular mortalities were identified with the Cox model. RESULTS: There were 45 (18 cardiovascular/27 non-cardiovascular) deaths occurred during follow-up. Age, diabetes, left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), carotid intima-media thickness (CIMT), and aortic pulse wave velocity (PWV) were significant predictors for all-cause and cardiovascular mortalities. After adjustment for age and diabetes, only LVEF was significantly associated with all-cause mortality. LVEF was significantly associated with cardiovascular mortality. LVEF remained as a significant independent predictor of cardiovascular death after adjusting for age, diabetes, LVMI, CIMT, or PWV, respectively. CONCLUSION: LVEF is the independent predictor for all-cause and cardiovascular mortalities in the normotensive hemodialysis patients.
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Yu et al. (2012) conducted a cohort in End-stage renal disease on hemodialysis (n=145). Left ventricular ejection fraction (LVEF) vs. Higher LVEF was evaluated on All-cause mortality (HR 0.97, 95% CI 0.95-0.99, p=0.015). In normotensive hemodialysis patients, left ventricular ejection fraction was an independent predictor of all-cause mortality, with a 3% reduction in risk per 1% increase in LVEF.
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