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October 1, 1975Proceedings of the National Academy of SciencesOpen Access

Effect of oncogenic virus on muscle differentiation.

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Population

Chick muscle cultures

Comparison

Infection with wild-type Rous sarcoma virus or a… vs Temperature-sensitive mutant at nonpermissive…

Design

Preclinical

Follow-up

Up to 8 days

Authors

HHHoward HoltzerThe Wistar InstituteJBJ. BiehlNew York UniversityGYGeorge C. YeohThe University of Western Australia

Discussion

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Implication

Reversible viral blockade of myogenesis in animal models should not change practice; leaves open roles in human muscle regeneration or disease.

Structured PICO

P
Population
Chick muscle cultures
I
Intervention
Infection with wild-type Rous sarcoma virus or a temperature-sensitive mutant (TS) at permissive temperatures
C
Comparator
Temperature-sensitive mutant (TS) at nonpermissive temperatures
O
Outcome
Myotube formation, vacuolation, degeneration, and cell transformationsurrogate

The study demonstrates that oncogenic viral gene expression reversibly blocks myogenesis depending on the cell's position in the myogenic program.

Cite This Study

Holtzer et al. (1975) studied this question.

synapsesocial.com/papers/6a20826bca5c5b2ddfa5e7a8https://doi.org/10.1073/pnas.72.10.4051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Muscle Differentiation in Cell Culture1972 · 68 citations
  2. 2Induction of thymidine<sup>−3</sup>h incorporation in multinucleated myotubes by rous sarcoma virus1968 · 51 citations
  3. 3MITOSIS AND THE PROCESSES OF DIFFERENTIATION OF MYOGENIC CELLS IN VITRO1969 · 321 citations
  4. 4Transformation of Chick Embryo Neuroretinal Cells by Rous Sarcoma Virus in vitro: Induction of Cell Proliferation1974 · 93 citations
  5. 5Thick and Thin Filaments in Postmitotic, Mononucleated Myoblasts1975 · 74 citations