Key result
Higher MDA-LDL levels linked to ~1% higher odds of central arterial stiffness in hemodialysis.
Why the study?
Circulating MDA-LDL is a marker of oxidative stress associated with atherosclerotic cardiovascular disease, but its relationship with aortic stiffness in hemodialysis patients required evaluation.
Are serum MDA-LDL levels associated with aortic stiffness in maintenance hemodialysis patients?
Cross-Sectional (n=155)
No
Are serum MDA-LDL levels associated with aortic stiffness in maintenance hemodialysis patients?
Odds Ratio: 1.014 (95% CI 1.007–1.021)
p-value: p=<0.001
High serum MDA-LDL levels are independently associated with increased aortic stiffness in maintenance hemodialysis patients, suggesting a role for oxidative stress in vascular complications.
Does not support routine MDA-LDL testing in hemodialysis; leaves open whether targeting oxidative stress reduces arterial stiffness.
Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) acts as a marker of oxidative stress and is associated with atherosclerotic cardiovascular disease. The relationship between serum MDA-LDL levels and aortic stiffness (AS) in patients with hemodialysis (HD) was evaluated. There were 155 HD patients enrolled in this study. Carotid-femoral pulse wave velocity (cfPWV) was measured by a validated tonometry system. Patients with cfPWV >10 m/s were used to define the AS group, while those with values of ≤10 m/s were regarded as the control group. Serum MDA-LDL levels were measured using a commercial enzyme-linked immunosorbent assay. Sixty-eight patients (43.9%) who were defined as AS sufferers, and were older, had a higher percentage of diabetes and hypertension and higher systolic blood pressure and serum MDA-LDL level compared to subjects in the control group. After adjusting for factors significantly associated with AS by multivariable logistic regression analysis, it was revealed that serum MDA-LDL levels, diabetes, and hypertension were independent predictors of AS in HD patients. Multivariable forward stepwise linear regression analysis also showed that a logarithmically transformed MDA-LDL level was significantly correlated with cfPWV values in HD patients. In HD patients, a high serum MDA-LDL level was positively associated with cfPWV values and was a significant predictor of the development of high AS.
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Hou et al. (2020) conducted a cross-sectional in End-stage renal disease on maintenance hemodialysis (n=155). Serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) vs. Lower MDA-LDL levels was evaluated on High central arterial stiffness (defined as carotid-femoral pulse wave velocity >10 m/s) (OR 1.014, 95% CI 1.007-1.021, p=<0.001). Higher serum malondialdehyde-modified low-density lipoprotein levels were an independent predictor of high central arterial stiffness in hemodialysis patients (OR 1.014).
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