Key result
Nine independent risk factors (e.g., cardiac shock, Killip class III-IV, EF ≤ 40%) significantly predicted in-hospital mortality among 384 AMI patients aged ≥ 80 years (overall mortality 23.4%).
Why the study?
The risk factors predicting in-hospital mortality among acute myocardial infarction patients aged 80 years and older needed to be explored.
Cohort (n=384)
No
In AMI patients aged 80 and older, in-hospital mortality is high (23.4%) and can be predicted by clinical factors such as shock, Killip class, and renal function.
May aid risk stratification in elderly AMI; observational data leaves open whether interventions improve outcomes.
OBJECTIVE: To explore the risk factors to predict mortality among acute myocardial infarction (AMI) patients aged ≥ 80 years during their hospitalization. METHODS: A cohort of AMI patients aged ≥ 80 years hospitalized in our hospital were recruited from 2005 to 2014. Variables, including demographics, medical history, hemodynamic condition and laboratory results, were collected and analyzed to find risk factors predicting mortality during hospitalization. RESULTS: Amonga total of 384 patients enrolled in this study, the hospital mortality rate was 23.4%. By multivariable stepwise regression analysis, nine independent significant predictors associated with mortality during hospitalization were identified: history of stoke, cardiac shock, Killip class III to IV, ventricular tachycardia, pulse rate ≥ 100 bpm and EF ≤ 40% at presentation, in-hospital bleeding, initial serum creatinine concentration ≥ 177 umol/L and elevated initial WBC level. Prior angina was identified as a protective factor. Hosmer-Lemeshow test indicated good fitness of the predicting variables. CONCLUSION: Patients aged 80 and over have high mortality during hospitalization, and the risk prediction factors are clinically useful for predicting mortality in old patients with AMI.
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Chen et al. (2019) conducted a cohort in Acute Myocardial Infarction (n=384). Clinical and laboratory risk factors vs. Absence of risk factors was evaluated on Mortality during hospitalization. Nine independent risk factors (e.g., cardiac shock, Killip class III-IV, EF ≤ 40%) significantly predicted in-hospital mortality among 384 AMI patients aged ≥ 80 years (overall mortality 23.4%).
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