What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Acute coronary syndrome (n=514). Intervention: Diabetes mellitus vs. Non-diabetic patients. Primary outcome: Myocardial infarction (vs unstable angina) (OR 2.4, p=<0.001).

What question did this study set out to answer?

The study aimed to assess the prevalence of diabetes mellitus and other cardiovascular risk factors in Iranian patients with acute coronary syndrome.

July 17, 2006Cardiovascular DiabetologyOpen Access

Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome

Q: What are the key findings of this study?

Diabetes was associated with a significantly higher rate of myocardial infarction compared to non-diabetic patients presenting with acute coronary syndrome (36.4% vs. 19.2%, OR 2.4).

Q: What question did this study set out to answer?

The study aimed to assess the prevalence of diabetes mellitus and other cardiovascular risk factors in Iranian patients with acute coronary syndrome.

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Key result

Diabetes was associated with a significantly higher rate of myocardial infarction compared to non-diabetic patients presenting with acute coronary syndrome (36.4% vs. 19.2%, OR 2.4).

Population

514 patients with unstable angina or myocardial infarction admitted to the CCU ward of a general hospital in…

Design

Cross-sectional

Authors

AEAlireza EsteghamatiUniversity of Minnesota MAMehrshad AbbasiImam Khomeini Hospital MNManouchehr NakhjavaniImam Khomeini Hospital

Discussion

Member takes

Implication

Extends diabetes-MI association to Iranian ACS patients; hypothesis-generating and should not yet change practice.

Key Points

The study aimed to assess the prevalence of diabetes mellitus and other cardiovascular risk factors in Iranian patients with acute coronary syndrome.
Included 514 patients with unstable angina or myocardial infarction from 720 admitted to CCU.
Detailed history of diabetes, hypertension, smoking, and lipid profiles were recorded.
Analyzed data using one-way ANOVA, T-tests, and chi-square tests.
30% of patients were diabetic, with a significant association between diabetes and myocardial infarction (36.4% vs. 19.2%, P < 0.001).
Diabetic patients were older than non-diabetics (65 +/- 11.6 vs. 59.7 +/- 12.5 years, P < 0.05).
97% had at least one cardiovascular risk factor; diabetes and hypertension were the most prevalent.

Study Design

Type

Cross-Sectional (n=514)

Multicenter

Structured PICO

Population

514 patients with acute coronary syndrome admitted to an Iranian hospital CCU, evaluated cross-sectionally for the prevalence of diabetes and cardiovascular risk factors.

Outcome

Prevalence of diabetes mellitus and other conventional coronary heart disease risk factors (cigarette smoking, hypertension, and hyperlipidemia)

Main Result

Odds Ratio: 2.4

Absolute Event Rate: 36.4% vs 19.2%

p-value: p=<0.001

In an Iranian population with acute coronary syndrome, 97% of patients had at least one conventional cardiovascular risk factor, with diabetes significantly increasing the likelihood of presenting with MI rather than unstable angina.

Limitations

Only collected records of in-hospital mortality, limiting conclusions about the effect of diabetes on overall ACS mortality
Single center, uncontrolled registry, cross-sectional study design limits generalizability and causal association testing
Lacked data concerning central obesity, insulin resistance, and minor/new cardiovascular risk factors such as albuminuria, homocystinemia, CRP, and adiponectin

Cite This Study

Esteghamati et al. (2006) conducted a cross-sectional in Acute coronary syndrome (n=514). Diabetes mellitus vs. Non-diabetic patients was evaluated on Myocardial infarction (vs unstable angina) (OR 2.4, p=<0.001). Diabetes was associated with a significantly higher rate of myocardial infarction compared to non-diabetic patients presenting with acute coronary syndrome (36.4% vs. 19.2%, OR 2.4).

synapsesocial.com/papers/6a20848315df8032213e9214 https://doi.org/10.1186/1475-2840-5-15

Topics

Women and heart disease Hypertension management

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Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider