Why the study?
Does multisite ventricular pacing improve cardiac function compared to single right ventricular apex pacing in dogs with normal hearts and pacing-induced heart failure without bundle branch block?
Population
Isoflurane-anesthetized dogs with normal hearts and dogs with heart failure induced by rapid ventricular…
Comparison
Multisite ventricular pacing and His-bundle… vs Single right ventricular apex (RVA) pacing.
Design
Preclinical
Follow-up
5 to 20 minutes
Key result
Four-site ventricular pacing significantly increased cardiac output by 8.5% (P<0.01) and positive dP/dt by 23.5% (P<0.001) compared with right ventricular apex pacing in dogs with heart failure.
Authors
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Should not yet change clinical pacing practice; hypothesis-generating for multisite ventricular pacing in HF without BBB.
Does multisite ventricular pacing improve cardiac function compared to single right ventricular apex pacing in dogs with normal hearts and pacing-induced heart failure without bundle branch block?
Effect estimate: 8.5% increase
p-value: p=<0.01
Multisite ventricular pacing significantly improves acute hemodynamic function compared with single right ventricular apex pacing in a canine model of heart failure without bundle branch block.
Lu et al. (1999) studied Heart failure. Four-site left and right ventricular apex and base (LRVAB) pacing vs. Right ventricular apex (RVA) pacing was evaluated on Cardiac output (8.5% increase, p=<0.01). Four-site ventricular pacing significantly increased cardiac output by 8.5% (P<0.01) and positive dP/dt by 23.5% (P<0.001) compared with right ventricular apex pacing in dogs with heart failure.